Program 28 : Bone marrow transplantation

Program 28 : Bone marrow transplantation


Pr Régis PEFFAULT DE LATOUR is currently the head of the Hematology and Bone Marrow Transplant Department, Hôpital Saint-Louis, Paris, France. He is the principal investigator of numerous research studies on bone marrow transplantation and authors of 300 papers quoted in pubmed.

Dr Karima YAKOUDEN, is a pediatric hematologist deeply involved in the Bone Marrow Transplantation and CAR  T-cell programs, within the children hematology and immunology facilities located in Robert-Debré Hospital. She participates in many research clinical trials in those fields.



Nathalie MILLAUD

P28 - Bone marrow transplantation


Cancer Care

  • One of the largest centers for allogeneic hematopoietic stem cell transplantation (HSCT) in adults and children in Europe.
    • Children transplantation facilities are located at Robert-Debré Hospital, entirely dedicated to pediatric diseases.
    • Saint-Louis Hospital is welcoming patients aged 15 years or more in two dedicated units according to their age (Adolescents and Young Adults [AYA] unit for patients aged less than 25 years and adult HSCT unit for the others).
  • Our department is certified by the standards and guidelines of the Joint Accreditation Committee ISCT-Europe & EBMT (JACIE), whose primary aim is to promote high-quality patient care and laboratory performance in hematopoietic stem cell collection, processing, and transplantation centers through an internationally recognized system of accreditation.
  • Beyond bedside care, our approach to transplantation includes laboratory research. We are focused on developing and evaluating promising new approaches for stem cell transplant to be able to offer the latest treatment advances to patients transplanted in our center. Our research is increasingly translational, which means that discoveries made in the laboratory are directly applied to our patients.
  • Multidisciplinarity: Working closely with healthcare professionals from other disciplines to decide upon the best possible treatment plan for the patients based on the available scientific evidence. This multidisciplinary approach encompasses both medical and paramedical staff, which is very helpful for the management of complications after HSCT.
  • Patients’ personal values and preferences are taken into account. Patient advocacy groups are thus very active in the field of transplantation at our Cancer Institute. EGMOS (Entraide aux Greffés de Moelle OSseuse) is working closely with healthcare professionals to provide the best possible care.
    • Information booklets provide information on clinical guideline recommendations and are produced either by the physicians or by the French society for stem cell transplantation (SFGM-TC).
    • Satisfaction surveys: Measuring patients’ perception of health service quality is of paramount importance to us. Most patients had a positive experience with visiting our clinics and perceived service provision as good. Those surveys are repeated regularly to ensure the quality of our service.


  • INSERM unit U976 : “Human immunology, pathophysiology, and immunotherapy” (, Team 4 – leader: Pr. S. Caillat-Zucman, Pr. G Socié


  • UMR168, Curie Institute : Immune reconstitution (Pr. G. Socié) and hematopoietic reconstitution (Dr. D. Michonneau)


  • Education and training go hand in hand with patient care.
  • Fellows, residents, and junior physicians are expected to develop clinical skills as well as interest in research in the course of the fellowship program.
  • We have participated in national and international educational courses on bone marrow transplantation on behalf of our scientific societies (French society for stem cell transplantation, European group for blood and marrow transplantation, European school of hematology, as well as American society of hematology).
  • Physicians are also actively involved in webinars and virtual platforms to disseminate knowledge worldwide and they contribute to the development of guidelines on all transplantation topics.
  • Nurses follow a similar path. New nurses are trained within the unit by experimented colleagues, with knowledge verification before integrating routine care. Virtual training and medical congress participation are encouraged at the national and international level. Clinical research is also promoted for voluntary nurses.