Programme 28 : Bone marrow transplantation

Programme 28 : Bone marrow transplantation


Pr Régis PEFFAULT DE LATOUR is currently the head of the Hematology and Bone Marrow Transplant Department, Hôpital Saint-Louis, Paris, France. He is the principal investigator of numerous research studies on bone marrow transplantation and authors of 300 papers quoted in pubmed.

Dr Karima YAKOUDEN, is a pediatric hematologist deeply involved in the Bone Marrow Transplantation and CAR  T-cell programs, within the children hematology and immunology facilities located in Robert-Debré Hospital. She participates in many research clinical trials in those fields.


Photo S. Vernois web 2022


Nathalie MILLAUD
P28 Bone marrow transplantation chiffres clés


Cancer Care

  • One of the largest centers for allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in adult and children in Europe.
    • Children transplantation facilities are located in Robert-Debré hospital, entirely dedicated to pediatric diseases.
    • Saint-Louis hospital is welcoming patients aged 15 years or more in 2 dedicated units according to patients’ age (Adolescents and Young Adults unit, AYA, for patients aged less than 25 years and adult HSCT unit for the others).


  • Our department is certified by the standards and guidelines of the Joint Accreditation Committee-ISCT (Europe) & EBMT (JACIE). JACIE’s primary aim is to promote high-quality patient care and laboratory performance at HSC-collection, -processing, and -transplantation centers through an internationally recognized system of accreditation.


  • Our approach to transplantation goes beyond the bedside to research in the laboratory. We are focused on developing and evaluating promising new approaches for stem cell transplant to be able to offer the latest treatment advances to people who have their transplants at our center. Our research is increasingly translational, which means that discoveries made in the lab are taken directly to our patients.


  • Multidisciplinarity: working closely with other care professionals from different disciplines to decide upon the best possible treatment plan for the patients based on the available scientific evidence. This multidisciplinary approach is involving a mix of medical as well as paramedical people very helpful in case of various complications after HSCT.


  • The patient’s personal values and preferences are elicited and acted upon. Patients advocacy groups are thus very active in transplantation at our Cancer Institute. EGMOS (Entraide aux Greffés de Moelle OSseuse) is working closely with health care professionals to provide the best care possible.
    • Information booklets explain the recommendations in a clinical guideline, produced either, by the physicians, but also by the French Society for stem cell transplantation (SFGM-TC).
    • Satisfaction surveys: measuring patients’ perception from health service quality is of outstanding importance for us. The majority of the patients had a positive experience with visiting clinics and perceived service provision as good. Those surveys are repeated regularly to ensure the quality of our service.


  • INSERM unit U976 : “Human immunology, pathophysiology and immunotherapy” (, team 4 – Team leader: Prof. S. Caillat-Zucman / Prof. G Socié


  • UMR168, Curie Institute : in collaboration with Dr Leila Périé, Team « Quantitative immuno-hematology” : Immune reconstitution (Pr Gérard Socié) and hematopoietic reconstitution (Dr David Michonneau)


  • Education and training go hand in hand with patient care.


  • Fellow, residents and junior physicians are expected to develop clinical skills as well as research interest the course of the fellowship program.


  • We have been participating to national and international educational courses in the field on behalf of our scientific societies (French Society for stem cell transplantation, European group for Blood and Marrow transplantation, European school of hematology as well as American society of Hematology).


  • Physicians are also deeply involved in Webinars and virtual platforms to disseminate knowledge worldwide as well as guidelines generation on all transplantation topics.


  • Similar trends have been developed for nurses. New nurses are trained within the unit by experimented colleagues with a knowledge verification before integrating routine care. Virtual training as well as medical congress participation are encouraged at the national and international level. Clinical research is also promoted for voluntary nurses.