Program 22 : Neuro-oncology

Program 22 : Neuro-oncology



Antoine Carpentier is Professor of Neurology and Neuro-Oncology at the University of Paris -Cité and head of the Department of Neuro-Oncology at the Saint-Louis Hospital, Paris, France. He is chairperson of the European Academy of Neurology (EAN) Panel of Neuro-Oncology and a member of the ANOCEF and the European Organization for Research of Treatment of Cancer (EORTC) Brain Tumor Group. Prof. Antoine Carpentier has longstanding experience in clinical and translational neuro-oncology. His clinical practice includes patients with primary brain tumors, metastatic brain cancers and leptomeningeal diseases. In the laboratory, his research is mainly focused on cancer immunotherapy. He has published more than 150 original papers in respected scientific journals.

Pr Philippe DECQ

Philippe Decq is Professor of Neurosurgery at Université Paris Cité and head of the Department of neurosurgery at Beaujon Hospital, Assistance Publique Hôpitaux de Paris, Clichy, France. Neurooncology is one of the main topic of the neurosurgical department, mainly focusing on malignant brain tumors and in particular on metastatic brain disease, in connection with the oncodermatology department of Saint Louis Hospital and the onco- thoracic department at Bichat Hospital. Several studies are being carried out on intrathecal immunotherapy and chemotherapy in collaboration with the Laboratory of Biological Pharmacology at Saint Louis Hospital and the INSERM UMR-S 1144 research unit (Therapeutic optimization in neuropsychopharmacology). The department is also a competence center for NF1 and organizes, in collaboration with the neurooncology department of Saint-Louis, a Grand Paris Nord neurooncology staff meeting, as well as for pituitary tumors with the endocrinology department of the Avicenne Hospital in Bobigny. . Philippe Decq is also invited professor at Human Biomechanical Institute of Arts et Métiers Paris for researches on head trauma and Hydrocephalus. He has published 115 original papers in per-reviewed scientific journals.

Pr Sébastien FROELICH

Sébastien Froelich is professor and chair of the neurosurgery department at Lariboisière Hospital, Assistance Publique – Hôpitaux de Paris, University of Paris Cité.

He obtained his MD and completed his residency at the university of Strasbourg. During his residency, he was awarded the research fellowship of the French speaking society of neurosurgery and was research fellow in 2000 at the department of neurosurgery, university of Cincinnati. In 2005-2006, he obtained advanced clinical fellowship training in skull base surgery at the department of neurosurgery, university of Cincinnati. In 2007, he became full professor of neurosurgery at university of Strasbourg and since 2014, he is chair of the department of neurosurgery at Lariboisière hospital in Paris.

Dr Froelich is renowned for his comprehensive treatment of complex brain tumors, skull base and CVJ lesions including pituitary adenomas, meningiomas, craniopharyngiomas, chordomas and chondrosarcomas. His clinical practice encompasses traditional open, minimally invasive endoscopic assisted and endonasal skull base approaches. He is also specialized in neurovascular surgery with an expertise in cerebrovascular bypass procedure for moya-moya, complex aneurysms and skull base tumors.

His research focuses on the tumorigenesis of chordomas, the link between progestins and meningiomas, and innovations in skull base surgery. He is director of the laboratory of experimental Neurosurgery in Lariboisière hospital, which focus on the development of innovative skull base and endoscopic technique, quantitative surgical neuroanatomy, virtual surgical simulation and the development of new surgical instrumentation and technology.

Dr Froelich has published over 180 peer-reviewed publications and 15 book chapters.

He is director since 2009 of hands-on skull base training program in IRCAD Strasbourg and Taiwan.

He is an active member of several national, European and international neurosurgical societies and served from 2017 to 2022 as the chairman of the skull base committee of the world Federation of the Neurological Societies. He is member of the board of the european skull base society and member of the World Academy of Neurosurgery.


Isabelle WOLF
P22 - Neuro-oncology


Cancer Care

The neuro-oncology axis of our institute brings together the concerted activities of the neuro-oncology department (Hôpital Saint Louis), and the two neurosurgery departments located at the Hôpital Lariboisière and Hôpital Beaujon. These activities concern both high- and low-grade glioblastomas, in addition to the management of brain metastases and leptomeningeal lesions using state-of-the-art technologies, such as awake glioblastoma surgery, intratumoral agents administered by pump, as well as others. The national and international expertise for certain rare tumors, including chordomas, skull base tumors, and cerebral lymphomas, should be highlighted. In addition, the neuro-oncology department is  very active in the management of immunotherapy, including immune checkpoint inhibitor and chimeric antigen receptor T (CART) cell toxicities. Overall, five multidisciplinary tumor boards have been set up for managing high- and low-grade glioblastomas, skull base tumors, vestibular schwannomas, and pituitary tumors.


  • Basic science:INSERM U970, Institut Curie (Y Bieche Lab), Institut de Biomécanique Humaine Georges Charpak ENSAM


– Regular participation to the ANOCEF (Association des Neuro-Oncologues d’Expression Française)guidelines

– Creation of an hypophyseal multidisciplinary team (MDT)

– Participation to the onco-dermatology MDT for metastases

– NF1 competence center

– Structuring of a research group focused on secondary central nervous system (CNS) lesions, including metastases and carcinomatous meningitis

Course Director for neurosurgery and skull base surgery:

  • IRCAD/EITS Strasbourg “Microscopic and endoscopic approach to the skull base”
    • 23 editions from 2010 to 2022
  • IRCAD/AITS Taichung, Taiwan “Microscopic and endoscopic approach to the skull base”
    • 4 days – Theoretical and practical sessions
    • Editions : from September 2010 to September 2014, December 2016, September 2018, and September 2019
  • IRCAD Africa Kigali “ Microscopic and endoscopic approach to the skull base”
    • 4 days – Theoretical and practical sessions
    • 1st Edition: January 2020
  • IRCAD China : First course in 2023
  • Neurosurgical skull base course Masterclass
    • Department of Neurosurgery, Lariboisière Hospital
      Course Director: Prof. Froelich
      Editions: March 2016, October 2016, May 2017, October 2017, April 2018, October 2018, April 2019, and October 2019
  • Lariboisière skull base course Masterclass
    • Department of Neurosurgery, Lariboisière Hospital
    • Course Director: Prof. Froelich
    • Editions: November 2017, May 2018, November 2018, May 2019, and November 2019
  • Participation in classes of: Diplôme inter-universitaire Européen “Joint European diploma of endoscopic skull base surgery”
  • Participation to the “Chordoma global consensus group” for drafting guidelines
    • Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, and Sommer J. Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group. Ann Oncol. 2017;28:1230-1242. doi: 10.1093/annonc/mdx054. PMID: 28184416; PMCID: PMC5452071.
    • Stacchiotti S, Sommer J; Chordoma Global Consensus Group. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol. 2015; 16:e71-83. doi: 10.1016/S1470-2045(14)71190-8. PMID: 25638683.
  • Participation to the drafting of the ANOCEF chordoma reference document

Writers: Bruno Chauffert, Georges Noel, Sebastien Froelich, Loic Feuvret, Elodie Vauléon, and Nicolas Penel