Programme 18 : Digestive Cancers

Programme 18 : Digestive Cancers

PROGRAM LEADERS

Pr Thomas APARICIO, is leader of Digestive Oncology at Saint-Louis Hospital, Professor of Medicine at University of Paris-Cité, medical director of medico-universitary department ICARE regrouping 11 oncology, surgery and inflammatory units. Member of the research team « intestinal Immunity in Inflammation and Cancer », INSERM 1160 at Institut de Recherche Saint Louis. He is the present president of the Fédération Francophone de Cancérology Digestive (FFCD), the main French research group on digestive oncology; He’s mains topic are oesogastric cancer, colorectal cancer, small bowel adenocarcinoma, oncogeriatry and immunotherapy. SIGAPS score: 2146 ; h-index: 41

Pr Vinciane REBOURS, MD, PhD, is head of the Pancreatology and Digestive Oncology Department at Beaujon Hospital. She is Professor of Medicine at Université Paris Cité. She is leading the first center for pancreatic diseases in France (inflammatory and tumoral diseases). The department is labeled as European center of excellence for neuroendocrine tumors. She is member of the INSERM UMR1149, team 9 « From inflammation to digestive cancers ». She was president of the European Pancreatic Club and the French Society of Gastroenterology. Her main topics of research are the relation between inflammation and pancreatic cancer and precancerous lesions. »

HEALTHCARE EXECUTIVE

Isabelle ABITBOL
P18 Digestive Cancer

STRENGTHS IN THE FOLLOWING AREAS

Cancer Care:

Our Institute represents one of the most important French center in digestive cancers, with more than 2 000 new patients yearly, 5 hospitals with digestive surgery and hepato-gastro-enterology departments, covering a vast region of more than 5 million of inhabitants, the great North Paris area. At Lariboisière and Saint-Louis hospitals the topics of excellence are oesophageal-gastric cancers, colorectal cancers, primitive peritoneal cancers and small intestine rare cancers. At Bichat Hospital, colorectal cancer patients represent the larger activity. At Beaujon hospital, the topics of excellence are represented by pancreas cancers, cholangiocarcinomas, hepatocarcinomas and is since 2009 the European reference center for digestive neuro-endocrine tumors (dedicated European Network EURANETS labelled “center of excellence” in that topic). Lastly Louis-Mourier Hospital as essentially an activity in colorectal cancers.  All kind of surgery techniques are available in our Institute, as well as all interventional techniques, either endoscopic (biliary prosthesis, echo-endoscopy) or CT-guided (radio-embolization, radio-frequency, cryotherapy, hepatic intra-arterial chemotherapy). Beaujon hospital is an expert center on the radiomics studies in hepatocarcinomas with a dedicated basic research unit and a Research dedicated hospital and University multidisciplinary program (RHU MOSAIC). Genomics routine diagnosis (DNA NGS and RNAseq) is available onsite with two large molecular biology and genetics platform at Saint-Louis and Bichat Hospital respectively with monthly molecular MTB at both sites, taking into account for the large volume of analyses. A dedicated Unit for hepatic transplantation is available for some patients with hepatic cancer at Beaujon. A dedicated onco-genetics team is available for patients and families with hereditary susceptibility gene alterations for counseling and follow-up. Clinical research activity is important with phase I to III trials and active participation to National groups (PRODIGE/FFCD groups) as European groups (EURANETS, EORTC). Prof. T. Aparicio is currently the Chair of the FFCD group of digestive cancers clinical research, sponsor of most of academic large French clinical trials and chairs the GCO organization gathering all academic cooperative cancer groups labelled by the French NCI (INCa).

Research:

  • FHU MOSAIC : L de Mestier, V. Rebours– Multiscale Optimized Strategy for Artificial Intelligence-based Imaging Biomarkers in Digestive Cancer (TNE)
  • MOSAIC-MIDAS-NET: Caractérisation moléculaire et imagomique des TNE intestinales F-DOPA avides – L de Mestier
  • INCA – Plan d’action intégré à la recherche : Phases précoces du cancer du pancréas associé à l’obésité et au syndrome métabolique : outils pour la prévention et le dépistage – Prof Couvelard, Prof Rebours

Basic science:

  • INSERM UMR1149- Centre de Recherche sur l’Inflammation – Team 9 : « From inflammation to cancers in digestive diseases »
  • INSERM UMR1149 – Laboratoire des Biomarqueurs en Imagerie
  • INSERM UMR1149 – Plasticity of gastro-intestinal mucosa in nutritional pathologies and after surgery
  • INSERM UMR 1160  centre de recherche de Saint-Louis : « Equipe inflammation et cancer digestifs »

Education:

An active participation of our local leaders to each annual meeting of FFCD for digestive cancers education is supported by their leadership. Prof. T. Aparicio is the coordinator of the residentship program of digestive oncology in Ile de France area and participates to 5 university national courses in digestive oncology. He is associate Editor of Digestive and Liver Disease (IF: 4.088), Journal of Geriatric Oncology (IF: 3.599), and Journal d’Oncogériatrie. Prof. Vinciane Rebours also participates to four university teaching programs dedicated mainly to pancreas cancer and digestive epithelium biology. She is the chair of the European Pancreatic club, and the elected president of the French Society of Hepato-gastro-enterology. She is associate editor for Pancreatology (IF: 3.996).  Prof.  Philippe Ruszniewski is the Dean of the Medical faculty of Université Paris Cité, and the Head of European Neuroendocrine Tumor Society (ENETs) Center of excellence, while also coordinating the centre Ile de France Nord from the national network of Neuro-endocrine tumors (RENATEN). He is in charge of the education module of ESMO “theranostics in NETs” while being associate editor of Neuroendocrinology journal.