PROGRAM LEADERS
Pr Valérie PARADIS, MD PhD and Professor in Pathology, is the chairman of Pathology department (Beaujon hospital) and leader of the INSERM team « From inflammation to neoplasia in digestive diseases » (INSERM UMR 1149, Paris). Her field of research include pathological and molecular aspects of chronic liver diseases and tumorigenesis with a specific interest in tumor heterogeneity. She is coordinating a collaborative FHU project MOSAIC aiming to identify imaging signatures “Imagomics” through integration of radiological and histological features and Artificial intelligence. She is a member of International groups of liver pathologists, Scientific commissions Research Institutes (INSERM, ANRS). She contributed to WHO Classification of Digestive Tumors and Clinical Practice Guidelines (Benign liver tumors & Occupational Liver Diseases).
Pr François ROUZET, MD PhD is the Head of the Nuclear Medicine Department at Bichat Hospital, Head of the preclinical imaging platform and Professor of Nuclear Medicine and Biophysics at Université Paris Cité. His research activities range from preclinical development of imaging agents, cardiovascular hybrid PET/MR, to clinical nuclear imaging. He authored >100 peer-reviewed articles mainly in the domains of myocardial perfusion, cardiac amyloidosis and infective endocarditis.
HEALTHCARE EXECUTIVE
Sévérine MOYNAT
STRENGTHS IN THE FOLLOWING AREAS
Cancer Care:
Imaging plays a key role in the management of cancer patients and is involved at each step of the disease and patient management: diagnosis, treatment, and follow-up. Imaging also contributes to cancer prevention and early detection, with specific programs dedicated to liver, lung, breast, and cutaneous tumors. Diagnostic imaging and pathology (DIP) is an interdisciplinary project supported by the DMU DREAM (coordinator: N. Siauve), which regroups all the imaging teams (radiology, nuclear medicine, and pathology) of the different APHP Nord sites in close collaboration with clinical and physiology departments.
Patient recruitment for imaging activity (radiology, nuclear medicine, and pathology) is mainly achieved through the on-site clinical teams. The specific activity of some imaging departments is shared for all patients from the APHP Nord according to the type of equipment and expertise required. In addition, specific recruitment for patients outside the APHP Nord (Ile-de-France and outside) is set up as follows:
Beaujon nuclear medicine: Radionuclide therapy [neuro-endocrine tumors (177Lu-dotatate), prostate cancer (177Lu-PSMA), radio-embolization (primary liver malignancies (Yttrium)]; PET/CT (public-private partnership (GCS) between the AP-HP and ELSAN group
Beaujon radiology: Participation to HOPE: one-day diagnosis for liver and pancreatic malignant tumors (V. Vilgrain & A. Sauvanet)
Bichat nuclear medicine: 68Ga-DOTATOC and 68Ga-PSMA PET/CT, F-DOPA PET/MR in primary and secondary brain tumors, sentinel lymph node detection
Lariboisière: Neuro-oncology (Fondation Adolphe de Rothschild Hospital and René Dubos Hospital)
Review, expertise
Imaging departments are involved in the review of all external cases presented at the multidisciplinary team meetings in oncology.
In addition, they receive consultation cases from outside the APHP Nord, mainly within the context of regional and national networks.
Research:
- 2 FHU: MOSAIC and APOLLO
- 1 RHU: OPERANDI
- 1 IHU: THEMA
Basic science: 6 teams
- INSERM UMR 1149 – Center of Research on Inflammation
- INSERM UMR 1152 – PHERE Physiopathology and epidemiology of respiratory diseases
- INSERM 1148 – LVTS
- INSERM UMR 976 – HIPI “Human immunology, pathophysiology, and immunotherapies”
- UMR 965 – Carcinosis, Angiogenesis and Translational Research Laboratory (CART)
- UMR 1141 – NeuroDiderot
Education:
DIP is highly involved in teaching thanks to the academic staff that engages in educational duties towards medical students and clinical/imaging practitioners. All imaging departments participate to weekly medical staff meetings on site and post-graduate courses dedicated to their own discipline (imaging & pathology). On behalf of the DMU DREAM and FHU MOSIAC, weekly webinars and monthly radiopathological correlation meetings are organized. Some members chair Master degrees, are involved in regional/national teaching in cancer imaging and radionuclide therapy, or participate in the national council of universities (CNU) of their discipline.